Disordered regions in transmembrane proteiins
Structurally transmembrane proteins are highly ordered in the membrane-spanning regions, but may contain disordered regions in the cytosolic and extra-cytosolic parts. We are involved in investigatie these disordered regions in transmembrane proteins. We applied a stringent definition of disordered residues on the currently available largest experimental dataset, and a significant correlation was found between the spatial distributions of positively charged residues and disordered regions. This finding suggests a new role of disordered regions in transmembrane proteins by providing structural flexibility for stabilizing interactions with negatively charged head groups of the lipid molecules.
People working on this project
|
Gábor E. Tusnády
|
|
László Dobson
|
Collaborating partners
Related publications
1.
Dobson, L, Mészáros, B and Tusnády, GE
( 2018)
Structural Principles Governing Disease-Causing Germline Mutations.
J Mol Biol
430:
4955-4970.
|
2.
Tusnády, GE, Dobson, L and Tompa, P
( 2015)
Disordered regions in transmembrane proteins.
Biochim Biophys Acta
1848:
2839-48.
|
|
|
