Disordered regions in transmembrane proteiins
Structurally transmembrane proteins are highly ordered in the membrane-spanning regions, but may contain disordered regions in the cytosolic and extra-cytosolic parts. We are involved in investigatie these disordered regions in transmembrane proteins. We applied a stringent definition of disordered residues on the currently available largest experimental dataset, and a significant correlation was found between the spatial distributions of positively charged residues and disordered regions. This finding suggests a new role of disordered regions in transmembrane proteins by providing structural flexibility for stabilizing interactions with negatively charged head groups of the lipid molecules.
People working on this project
| Gábor E. Tusnády |
| László Dobson |
Collaborating partners
| Péter Tompa VIB Structural Biology Research Center |
Related publications
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1.
Dobson, L, Mészáros, B and Tusnády, GE
(2018)
Structural Principles Governing Disease-Causing Germline Mutations.
J Mol Biol
430:
4955-4970.
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2.
Tusnády, GE, Dobson, L and Tompa, P
(2015)
Disordered regions in transmembrane proteins.
Biochim Biophys Acta
1848:
2839-48.
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3.
Dobson, L and Tusnády, GE
(2021)
MemDis: Predicting Disordered Regions in Transmembrane Proteins.
Sci Rep
22:
.
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Recent publications
News
| 2020-06-02 - Paper published |
| 2019-03-08 - PhD degree |
| 2019-02-07 - Paper published |
| 2018-11-14 - Scientific Students' Association third prize |
| 2018-10-30 - Paper published |