Welcome to the Protein Bioinformatics Research Group!
The Protein Bioinformatics Research Group at the Institute of Molecular Life Sciences (former name: Institute of Enzymology), Research Centre of Natural Sciences is headed by Dr. Gábor Tusnády, and was founded in 2012, when the PI won the Momentum Prize of the Hungarian Academy of Sciences.
The group's main aim is to investigate membrane proteins topology and 3D structure by developing state-of-the-art computational techniques, like CCTOP or TmAlphaFold as well as to establish and maintain databases and servers relating to transmembrane protein structure and topology. These resources provide valuable help to understand the role of disordered regions in membrane proteins, how disease-causing mutations perturb their structure or protein sorting in polarized cells. Beyond bioinformatics studies, the group is involved in developing high throughput experimental methods for generating topology data of transmembrane proteins.
In addition to these recent achievements in the field of transmembrane proteins, the group was involved in several studies using next generation sequencing (NGS) ranging from genome sequencing of the chicken DT40 bursal lymphoma cell line and Mycoplasma sp. HU2014, through studying mutagenic impact of common cancer cytotoxics and clinical validation of TruSeq Custom Amplicon assay performed on formalin-fixed and paraffin-embedded tumor samples, to the identification of known and unknown plant viral pathogens.
Recent publications
News
2020-06-02 - Paper published |
2019-03-08 - PhD degree |
2019-02-07 - Paper published |
2018-11-14 - Scientific Students' Association third prize |
2018-10-30 - Paper published |